Hyperalgesia induced by naloxone follows diurnal rhythm in responsivity to painful stimuli

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Science  18 Nov 1977:
Vol. 198, Issue 4318, pp. 756-758
DOI: 10.1126/science.561998


A diurnal rhythm was observed in the responsiveness of mice to nociceptive stimuli and in the hyperalgesic activity of endogenous opioid peptides and may partly account for previous controversy over the direct action of naloxone in opiate-naive animals.