Benzodiazepine receptor: demonstration in the central nervous system

Science  25 Nov 1977:
Vol. 198, Issue 4319, pp. 849-851
DOI: 10.1126/science.918669


Diazepam, a potent minor tranquilizer, binds with high affinity to a specific benzodiazepine receptor that occurs exclusively in the central nervous system. The receptor is mainly localized in the synaptic membrane fraction. Binding to the receptor is stereospecific. Competition for the receptor by various benzodiazepines closely parallels their pharmacological potency.

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