Regions of cerebral ischemia located by pyridine nucleotide fluorescence

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Science  02 Dec 1977:
Vol. 198, Issue 4320, pp. 951-953
DOI: 10.1126/science.201026


The fluorescence of the reduced form of the endogenous pyridine nucleotide nicotinamide adenine dinucleotide was used to map regions of ischemia in cat brain. A remarkably microheterogeneous pattern of increased fluorescence resulted from a critical level of incomplete cerebral ischemia. The fluorescence pattern suggests that ischemia occurs initially in microwatershed zones between penetrating cerebral arteries.