Cytidine 3',5'-monophosphate (cyclic CMP) formation in mammalian tissues

Science  09 Dec 1977:
Vol. 198, Issue 4321, pp. 1063-1065
DOI: 10.1126/science.22127


Mammalian tissues possess the capacity to synthesize cytidine 3',5'-monopHosphate (cyclic CMP) via the enzymatic conversion of cytidine 5'-triphosphate to cyclic CMP by cytidylate cyclase. Cyclic CMP formation occurs best in the presence of manganese or iron, at neutral pH, at 37 degrees C, in the absence of detergents, and with whole tissue homogenate fractions. Thus, mammalian tissues are capable of synthesizing not only cyclic AMP and cyclic GMP, but also cyclic CMP.