Polymorphonuclear leukocytes: possible mechanism of accumulation in psoriasis

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Science  16 Dec 1977:
Vol. 198, Issue 4322, pp. 1162-1163
DOI: 10.1126/science.929193


Extracts of involved and uninvolved skin from nine patients with untreated psoriasis were studied for chemotactic activity. Psoriatic plaque contains increased amounts of a complement-dependent chemotactic factor that is inhibited by diisopropyl fluorophosphate. This factor may be human skin serine proteinase.