Polychlorobornane components of toxaphene: structure-toxicity relations and metabolic reductive dechlorination

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Science  23 Dec 1977:
Vol. 198, Issue 4323, pp. 1256-1258
DOI: 10.1126/science.929197


2,2,5-endo,6-exo,8,9,10-Heptachlorobornane and four derivatives of this heptachlorobornane, with an additional chlorine atom at position 3-exo,8,9, or 10, account for a major portion of the acute toxicity of toxaphene and for up to 23 percent of toxaphene composition as analyzed by open tubular column gas-liquid chromatography with an electron capture detector. Both in several organisms and model environmental systems and on photolysis, this heptachlorobornane undergoes facile reductive dechlorination at the geminal-dichloro group and sometimes dehydrochlorination.