Genetic Defect in Biosynthesis of the Precursor Form of the Fourth Component of Complement

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Science  06 Jan 1978:
Vol. 199, Issue 4324, pp. 69-70
DOI: 10.1126/science.199.4324.69


Under cell-free conditions, liver polysomes from guinea pigs genetically deficient in the fourth component of complement (C4) did not synthesize pro-C4 (the precursor of C4), but did synthesize nascent C4 polypeptides which remained polysome bound. The defect was specific for pro-C4 synthesis since the amounts of total protein and albumin synthesis and release from C4-deficient polysomes were similar to that in normal guinea pig liver polysomes.