Antibody-Dependent Lymphocytotoxicity Induced by Immunoglobulin G from Hodgkin's Disease Splenic Lymphocytes

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Science  06 Jan 1978:
Vol. 199, Issue 4324, pp. 71-72
DOI: 10.1126/science.199.4324.71


Immunoglobulin G, produced in cultures of splenic lymphocytes obtained from patients with Hodgkin's disease, bound to a population of homologous peripheral blood lymphocytes and initiated antibody-dependent cell cytotoxicity in cultures from five out of eight patients. Two patients whose cultures produced negative results had minimal disease; the other was in remission. The target cells appear to be T lymphocytes; the effector cells bear Fc receptors that are inhibited by antigen-antibody complexes. Antibody-dependent cell cytotoxicity events may produce the anergy and lymphopenia often seen in Hodgkin's disease.