Choline Administration: Modification of the Central Actions of Atropine

Science  06 Jan 1978:
Vol. 199, Issue 4324, pp. 86-87
DOI: 10.1126/science.199.4324.86


The anticholinergic agent atropine decreases acetylcholine concentrations and increases high-affinity choline uptake in cortical and hippocampal regions of rat brain. Administration of choline 1 hour before atropine prevents both of these atropine-induced alterations. These findings suggest that alterations in acetylcholine precursor availability may modify the effects of centrally active anticholinergic agents.