Reports

Phenobarbital: Effects of Long-Term Administration on Behavior and Brain of Artificially Reared Rats

+ See all authors and affiliations

Science  06 Jan 1978:
Vol. 199, Issue 4324, pp. 90-91
DOI: 10.1126/science.199.4324.90

Abstract

Two doses of phenobarbital were given daily for 2 weeks to infant rats fed by intragastric cannulas. The larger dose (60 milligrams per kilogram of body weight) resulted in decreased spontaneous activity and increased responses to novel stimuli. The smaller dose (15 milligrams per kilogram) resulted in increased spontaneous activity and also an increase of responses to novel stimuli. The larger dose produced a 12 percent reduction in brain growth, while the smaller dose was associated with a 3 percent reduction in brain growth.