Phosphorylated proteins as physiological effectors

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Science  13 Jan 1978:
Vol. 199, Issue 4325, pp. 146-152
DOI: 10.1126/science.22932


A variety of neurotransmitters, hormones, and other regulatory agents affect the phosphorylation of specific proteins in their target tissues. The types of stimuli that share this common effect on protein phosphorylation include numerous substances that do not act through cyclic AMP. These and other observations suggest that many different classes of regulatory substances achieve certain of their biological effects by altering the phosphorylation of specific proteins.