Environmental hydrocarbons produce degeneration in cat hypothalamus and optic tract

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Science  13 Jan 1978:
Vol. 199, Issue 4325, pp. 199-200
DOI: 10.1126/science.413192


2,5-Hexanedione, the principal neurotoxic metabolite of the industrial solvents n-hexane and methyl n-butyl ketone causes axonal degeneration in the mammillary body and visual nuclei of cats. Prolonged, low-level exposure to hydrocarbons in the environment may cause premature deterioration in areas of the human brain vital for perception and behavior.