Acceleration of plasma bicarbonate conversion to carbon dioxide by pulmonary carbonic anhydrase

See allHide authors and affiliations

Science  27 Jan 1978:
Vol. 199, Issue 4327, pp. 427-429
DOI: 10.1126/science.413195


In isolated rabbit lungs perfused with solutions containing little or no carbonic anhydrase activity, nearly complete equilibration between H14CO3- and 14CO2 occurs during a single circulation. This equilibration can be inhibited by blocking pulmonary carbonic anhydrase with acetazolamide.