Cyclopropanecarboxylic acid: chain elongation to omega-cyclopropyl fatty acids by mammals and plants

Science  03 Feb 1978:
Vol. 199, Issue 4328, pp. 544-545
DOI: 10.1126/science.622554


Rats dosed orally which [carboxyl-14C]cyclopropanecarboxylic acid (or its hexadecyl ester) retain radioactivity in tissue as novel triacylglycerols. The most abundant 14C-labeled metabolites were identified by gas-liquid chromatography-mass spectrometry as 13-cyclopropyltridecanoic and 15-cyclopropylpentadecanoic acids. Similar omega-cyclopropyl fatty acids are produced by beagle dogs and a lactating cow, as well as by apple and orange trees.