Limitation of excessive myelopoiesis by the intrinsic modulation of macrophage-derived prostaglandin E

Science  03 Feb 1978:
Vol. 199, Issue 4328, pp. 552-555
DOI: 10.1126/science.304600


The clonal proliferation of the committed granulocyte-macrophage stem cell is controlled by a balance between mutually opposing factors, colony stimulating factor and prostaglandin E, both of monocyte-macrophage derivation. Increases beyond a critical concentration of colony stimulating factor within the local milieu of the mononuclear phagocyte induces the coincident elaboration of prostaglandin E, a self-regulated response which serves to limit the unopposed humoral stimulation of myelopoiesis.