L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment

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Science  17 Feb 1978:
Vol. 199, Issue 4330, pp. 775-776
DOI: 10.1126/science.622565


L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.