Cholestyramine: use as a new therapeutic approach for chlordecone (kepone) poisoning

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Science  24 Feb 1978:
Vol. 199, Issue 4331, pp. 893-895
DOI: 10.1126/science.74852


In rats, as reported in humans, chlordecone (Kepone) is excreted predominantly in the feces. Cholestyramine, an anion exchange resin, binds chlordecone in rat intestine, increases its excretion into the feces, and decreases its content in the tissues. The resin appears to offer a practical method for treating chronic poisoning with this and possibly with other lipophilic toxins.