Reports

Sulfhydryl groups and the monodeiodination of thyroxine to triiodothyronine

Science  24 Feb 1978:
Vol. 199, Issue 4331, pp. 904-906
DOI: 10.1126/science.622575

Abstract

Sulfhydryl reagents exert a profound influence on the monodeiodination of thyroxine to triiodothyronine by rat and sheep tissues in vitro. A marked dithiothreitol-induced increase in the monodeiodination by fetal sheep liver homogenates suggests that the characteristically low conversion in fetal tissues is related more to the status of sulfhydryl groups than to a deficiency of the monodeiodinating enzyme.

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