Inhibition of Carbonic Anhydrase by Anions in the Carbon Dioxide-Bicarbonate System

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Science  24 Feb 1978:
Vol. 199, Issue 4331, pp. 907-909
DOI: 10.1126/science.199.4331.907


Chloride and iodide ions exhibit noncompetitive inhibition of carbon dioxide hydration catalyzed by bovine carbonic anhydrase and competitive inhibition of bicarbonate dehydration. Consideration of the net velocity at equilibrium leads to a satisfactory resolution of the dilemma concerning the different concentrations of such anions required to halve the initial reaction rate for each substrate.