Cyclic adenosine monophosphate production by embryonic chick cells

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Science  03 Mar 1978:
Vol. 199, Issue 4332, pp. 990-991
DOI: 10.1126/science.203037


Cells dissociated from 1-day-old chick embryos produce a pulse of cyclic adenosine monophosphate (cyclic AMP) when stimulated with cyclic AMP. There is a stimulus threshold concentration of about 10(-8) molar cyclic AMP and an upper limit, above which the response is suppressed, of about 6 X 10(-6) molar. The response occurs within 5 seconds of stimulation and corresponds to an average pulse size in the range of 10(7) molecules per cell.