Platelet factor 4: an inhibitor of collagenase

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Science  03 Mar 1978:
Vol. 199, Issue 4332, pp. 991-992
DOI: 10.1126/science.203038


Human platelet factor 4 (PF4) is known to bind to heparin and inhibit its anticoagulant effect. This factor also inhibits the enzyme collagenase derived from cultured human skin and collagenase extracted from human granulocytes. The addition of heparin to the PF4-collagenase assay system has no effect on the observed inhibition of collagenase. Thus PF4 inhibits collagenase, in addition to neutralizing heparin.