Irreversible inhibition of sodium entry sites in frog skin by a photosensitive amiloride analog

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Science  17 Mar 1978:
Vol. 199, Issue 4334, pp. 1205-1206
DOI: 10.1126/science.305114


A photosensitive binding reaction is described in which an analog of amiloride is bound to sites that control sodium entry into frog skin. This reaction results in irreversible inhibition of net sodium transport.