Opiate receptors for behavioral analgesia resemble those related to the depression of spinal nociceptive neurons

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Science  17 Mar 1978:
Vol. 199, Issue 4334, pp. 1231-1233
DOI: 10.1126/science.204008


With naloxone as antagonist, a dose-ratio analysis of the depression by morphine of nociceptive neurons in the spinal cord reveals that this opiate depression of single unit activity has the same pharmacological properties as observed with morphine analgesia. This suggests that the opiate receptor, mediating the observed cellular depression, and those mediating analgesia are presumably the same.