Inhibition of bone resorption in vitro by a cartilage-derived anticollagenase factor

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Science  24 Mar 1978:
Vol. 199, Issue 4335, pp. 1342-1345
DOI: 10.1126/science.204011


A cartilage-derived factor containing a specific collagenous inhibitor was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. Morphologic and quantitative histometric examination revealed that this factor modulates osteoclastic activities.