Erythroid progenitors circulating in the blood of adult individuals produce fetal hemoglobin in culture

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Science  24 Mar 1978:
Vol. 199, Issue 4335, pp. 1349-1350
DOI: 10.1126/science.628844


Erythroid colonies, raised from erythroid stem cells circulating in the peripheral blood of normal adult individuals, synthesize considerable amounts of fetal hemoglobin. In cultures from persons with sickling disorders, amounts of hemoglobin F that are known to inhibit sickling in vivo are produced. The results provide evidence that primitive erythroid progenitors are able to express the hemoglobin F production program and that cultures of mononuclear cells of the adult blood can be used to investigate the mechanisms involved in regulation of gamma-globin gene switching.