Opiate peptide modulation of amino acid responses suggests novel form of neuronal communication

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Science  31 Mar 1978:
Vol. 199, Issue 4336, pp. 1451-1453
DOI: 10.1126/science.204016


Mouse spinal neurons grown in tissue culture were used to study the electrophysiological pharmacology of the opiate peptide leucine-enkephalin. Enkephalin depressed glutamate-evoked responses in a noncompetitive manner independent of any other effects on membrane properties. The results demonstrate a neuromodulatory action of opiate peptide functionally distinct from the conventional neurotransmitter class of operation.