Muscular dystrophy: inhibition of degeneration in vivo with protease inhibitors

Science  07 Apr 1978:
Vol. 200, Issue 4337, pp. 50-51
DOI: 10.1126/science.635570


The protease inhibitors leupeptin and pepstatin were used in vivo in genetically dystrophic chickens to determine their effects on the histological and biochemical changes observed in this disease. These compounds appear to delay the degeneration of muscle tissue which is characteristic of this disorder and thus may have potential therapeutic value in the treatment of muscular dystrophy.