Preferential utilization of free cholesterol from high-density lipoproteins for biliary cholesterol secretion in man

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Science  07 Apr 1978:
Vol. 200, Issue 4337, pp. 62-64
DOI: 10.1126/science.204996


High- and low-density lipoproteins carrying free cholesterol labeled with 3H or 14C were administered to a patient with a bile fistula. The free cholesterol from high-density lipoproteins was more rapidly incorporated into biliary cholesterol than the free cholesterol from low-density lipoproteins. These findings show that the liver in man selectively utilizes and secretes the free cholesterol from a particular lipoprotein.