Neurotrophic protein regulates muscle acetylcholinesterase in culture

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Science  21 Apr 1978:
Vol. 200, Issue 4339, pp. 337-339
DOI: 10.1126/science.635593


Skeletal muscles lose acetylcholinesterase in culture as a result of denervation. A protein fraction isolated from peripheral nerves maintained the level of acetylcholinesterase in cultures of aneural embryonic muscle or denervated adult chicken muscle. These results indicate that trophic regulation of muscle acetylcholinesterase might be mediated by a protein produced by nerves.