Channel structures of gramicidin: characterization of succinyl derivatives

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Science  28 Apr 1978:
Vol. 200, Issue 4340, pp. 435-437
DOI: 10.1126/science.77040


Succinyl derivatives of gramicidin were tested for their ability to form channels in planar artificial lipid bilayers. Both N-succinyldeformylgramicidin methyl ester and charged O-succinylgramicidin formed channels, but the channels had markedly different sizes and lifetimes. This implies that gramicidin forms channels by end-to-end association. However, the doubly charged N,O-bissuccinyldeformylgramicidin was inactive, which suggests that only end-to-end association of gramicidin may result in channel formation.