Delayed hypersensitivity in man: effects of systemic anticoagulation

Science  05 May 1978:
Vol. 200, Issue 4341, pp. 541-543
DOI: 10.1126/science.644314


Skin test reactivity, lymphocyte transformation, and mononuclear cell tissue factor generation were evaluated both before and during systemic anticoagulation in 24 volunteers. Anticoagulation with warfarin decreased skin test induration and tissue factor generation, but lymphocyte trnasformation remained unchanged. An intact coagulation mechanism, including tissue factor generation, appears to be important for the development of skin test induration in humans.