Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells

Science  05 May 1978:
Vol. 200, Issue 4341, pp. 556-559
DOI: 10.1126/science.644318


When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine. Other tumor-promoting macrocyclic plant diterpenes also inhibit neurite formation, whereas nonpromoting diterpenes do not. Inhibition by TPA was reversible and was unrelated to toxicity.