ArticlesDiagnosis and Therapeutics

Prenatal diagnosis of genetic disorders

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Science  26 May 1978:
Vol. 200, Issue 4344, pp. 952-958
DOI: 10.1126/science.77042


Sampling of amniotic fluid, visualization of the fetus, fetal blood sampling, and screening of maternal blood represent successive approaches to the diagnosis of specific genetic disorders in the second trimester of pregnancy. Clinical and ethical concerns about the appropriateness, safety, and efficacy of the techniques have led to multidisciplinary assessments at an early stage. A major growth in demand for medical and educational genetic services can be anticipated.