Effect of oxygen pressure during culture on survival of mouse thyroid allografts

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Science  02 Jun 1978:
Vol. 200, Issue 4345, pp. 1066-1067
DOI: 10.1126/science.653355


A marked increase in the percentage of mouse thyroids that retained function 20 days after transplantation across a major histocompatibility barrier and the percentage that lacked generalized infiltration was observed when the grafts received hyperbaric oxygen during a 4-day culture period. Perfusion of the donor animal before thyroidotomy and the addition of fetal calf serum to the culture medium did not have a significant effect on graft survival, but the percentage of grafts lacking generalized infiltration was slightly increased by the addition of hydrocortisone to the culture medium.