Amino acid sequence of the Fc region of a canine immunoglobulin M: interspecies homology for the IgM class

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Science  09 Jun 1978:
Vol. 200, Issue 4346, pp. 1159-1161
DOI: 10.1126/science.653360


The amino acid structure for the Fc portion of a canine immunoglobulin mu chain was determined. The sequence was compared with those of two human mu chains, and a high degree of interspecies homology was observed. The preservation of primary structure between species is probably reflective of the unique functions associated with the immunoglobulin M class.