Potent antidopaminergic activity of estradiol at the pituitary level on prolactin release

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Science  09 Jun 1978:
Vol. 200, Issue 4346, pp. 1173-1175
DOI: 10.1126/science.418505


Prior incubation of rat anterior pituitary cells with 17beta-estradiol led to an almost complete reversal of the inhibitory effect of two dopamine agonists, dihydroergocornine and RU 24213, on both basal prolactin release and thyrotropin releasing hormone-induced prolactin release. These experiments thus demonstrate a direct interference of dopamine action by a peripheral hormone. Prolactin secretion by pituitary cells in primary culture could possibly serve as an easily accessible model of a system under dopaminergic control.