Thrombin-induced platelet aggregation is mediated by a platelet plasma membrane-bound lectin

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Science  16 Jun 1978:
Vol. 200, Issue 4347, pp. 1281-1283
DOI: 10.1126/science.663608


Throbin-activated human platelets cause agglutination of trypsinized, formalinized bovine erythrocytes. This lectin activity of stimulated platelets was blocked by galactosamine, glucosamine, mannosamine, lysine, and arginine, but not by N-acetylated sugars, other neutral sugars, or other amino acids. Inhibitors of the thrombin-induced lectin activity also blocked thrombin-induced platelet aggregation. It appears that a membrane surface component that has lectin activity mediates platelet aggregation.