Isolated retinas synthesize visual pigments from tetinol congeners delivered by liposomes

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Science  23 Jun 1978:
Vol. 200, Issue 4348, pp. 1393-1395
DOI: 10.1126/science.307275


Isolated vertebrate retinas bathed in circulating Ringer solution cannot regenerate all of their bleached visual pigments. When dioleoyl-lecithin vesicles containing certain retinol congeners are added to the Ringer solution, such retinas begin to regenerate pigment immediately. The visual pigment of a bleached perfused retina can now be restored fully, making the isolated retina an independent unit for study. Loposomes can protect oxygen-sensitive, lipid-soluble substances and deliver them to living cells.