Sympathetic nervous control of cerebrospinal fluid production from the choroid plexus

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Science  14 Jul 1978:
Vol. 201, Issue 4351, pp. 176-178
DOI: 10.1126/science.663649


The rabbit choroid plexus, responsible for the bulk production of cerebrospinal fluid, is well supplied by sympathetic nerves emanating in the superior cervical ganglia. Electrical stimulation of these nerves markedly reduces production of cerebrospinal fluid, measured by [14C] inulin dilution during ventricular perfusion, whereas sympathetic denervation enhances the rate of formation.