Estrogenic activity of the insecticide kepone on the chicken oviduct

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Science  28 Jul 1978:
Vol. 201, Issue 4353, pp. 356-358
DOI: 10.1126/science.78523


Kepone induces ovalbumin and conalbumin synthesis in explants of chick oviduct in vitro by acting as a weak estrogen. It binds to the nuclear estrogen receptor and is antagonized by the antiestrogen tamoxifen. Kepone also induces egg white protein synthesis in vivo by direct interaction with estrogen receptors and by indirectly increasing the concentration of progesterone in the serum.