Reports

Brain edema: induction in cortical slices by polyunsaturated fatty acids

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Science  28 Jul 1978:
Vol. 201, Issue 4353, pp. 358-360
DOI: 10.1126/science.663662

Abstract

The presence of polyunsaturated and saturated fatty acids in leukocytic membranes prompted study of their possible role in the induction of brain edema. Polyunsaturated fatty acids including sodium arachidonate, sodium linoleate, sodium linolenate, and docasahexaenoic acids induced edma in slices of rat brain cortex. This cellular edema was specific, since neither saturated fatty acids nor a fatty acid containing a single double bond had such effect.