Disulfiram enhances pharmacological activity of barbital and impairs its urinary elimination

See allHide authors and affiliations

Science  11 Aug 1978:
Vol. 201, Issue 4355, pp. 543-544
DOI: 10.1126/science.663674


Disulfiram or diethyldithiocarbamate significantly enhanced the sleeping time induced by barbital in rats. At identical time intervals after rats were injected with barbital the concentration of barbital in the blood or brain of animals that had previously received disulfiram was significantly higher than the concentrations in the corresponding tissues of control animals. Urinary excretion of barbital was significantly reduced in disulfiram-treated animals.