Left ventricular receptors inhibit brain serotonin neurons during coronary artery occlusion

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Science  18 Aug 1978:
Vol. 201, Issue 4356, pp. 620-622
DOI: 10.1126/science.675245


Acute coronary artery ligation in pargyline-treated rats decreased serotonin and increased 5-hydroxyindoleacetic acid in the medulla and posterior hypothalamus. Lidocaine applied topically to the left ventricle completely prevented these alterations. No changes in serotonin were observed in the other brain regions examined. These data suggest a reflex inhibition of bulbar and hypothalamic serotonergic nerves by left ventricular receptors following acute coronary artery occlusion in the rat.