Aminophylline increases cerebral metabolic rate and decreases anoxic survival in young mice

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Science  18 Aug 1978:
Vol. 201, Issue 4356, pp. 649-651
DOI: 10.1126/science.209541


In weanling mice treated with pharmacologic doses of aminophylline, the concentrations of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in the brain increased 44 and 36 percent, respectively, and the cerebral metabolic rate was three times that in controls. In neonatal mice, therapeutic doses of aminophylline greatly decreased the rate of anoxic survival in vivo and the duration of gasping of the isolated head. The findings suggest caution in the use of this drug and other methylxanthines in hypoxic human newborns.