Reports

Trisodium phosphonoformate, a new antiviral compound

+ See all authors and affiliations

Science  01 Sep 1978:
Vol. 201, Issue 4358, pp. 819-821
DOI: 10.1126/science.210500

Abstract

Trisodium phosphonoformate selectively inhibits cell-free DNA polymerase activity induced by herpesvirus. The new inhibitor has an antiviral effect on herpes simplex virus types 1 and 2, pseudorables virus, and infectious bovine rhinotracheitis virus in cell culture. It has a good therapeutic activity against cutaneous herpes simplex virus infection in guinea pigs.