Growth inhibition of transformed cells with succinylated concanavalin A

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Science  01 Sep 1978:
Vol. 201, Issue 4358, pp. 824-826
DOI: 10.1126/science.210502


Succinylated concanavalin A reversibly inhibits the growth of SV40 transformed mouse 3T3 cells and thus causes an accumulation of the cells in the G1 phase of the cell cycle. In a soft substrate (methylcellulose) succinylated concanavalin A also restores in transformed cells the growth behavior typical of untransformed cells.