Jaundice phototherapy: micro flow-cell photometry reveals rapid biliary response of Gunn rats to light

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Science  01 Sep 1978:
Vol. 201, Issue 4358, pp. 829-831
DOI: 10.1126/science.581101


Hepatic pigment clearance in rats can be followed continuously with photometric detectors designed for high-pressure liquid chromatography. This method showed that light has a fast effect on bilirubin metabolism in homozygous Gunn rats, even at low doses and intensities. This is consistent with geometric isomerization of bilirubin IXalpha as a primary step in phototherapy.