Vitamin D: two dihydroxylated metabolites are required for normal chicken egg hatchability

See allHide authors and affiliations

Science  01 Sep 1978:
Vol. 201, Issue 4358, pp. 835-837
DOI: 10.1126/science.684411


When hens are raised to sexual maturity from hatching with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] as their sole source of cholecalciferol (vitamin D3), fertile eggs appear to develop normally but fail to hatch. When hens receive a combination of 1,25(OH)2D3 and 24R,25-dihydroxyvitamin D3 [24,25(OH)2D3], hatchability equivalent to that with hens given vitamin D3 is obtained. These results suggest a biological role for 24,25(OH)2D3 not previously recognized.