Rebound insomnia: a new clinical syndrome

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Science  15 Sep 1978:
Vol. 201, Issue 4360, pp. 1039-1041
DOI: 10.1126/science.684426


Rebound insomnia followed the withdrawal of three benzodiazepine hypnotic drugs, each of which had been administered in a single nightly dose for only short-term periods. The intense worsening of sleep is attributed to the short duration of the action of these drugs. A hypothesis involving benzodiazepine receptors in the brain is proposed in which there is a delay or lag in replacement of endogenous benzodiazepine-like molecules after the abrupt withdrawal of exogenous drugs.