Manufactured hexaparental mice show that adults are derived from three embyronic cells

Science  06 Oct 1978:
Vol. 202, Issue 4363, pp. 56-58
DOI: 10.1126/science.694518


Two female chimeric mice have been produced by aggregates of three genetically marked eight-cell embryos. All three embryonic genotypes are clearly expressed in the pigment pattern of the adults. These hexaparental mice together with their littermates demonstrate that, in the 64-celled blastocyst, at least three cells, and probably only three, are the source of all adult tissues.